Considering that ketamine infused in a sub-anesthetic dose, integrated with behavioral treatment, has been shown to reduce alcohol and cocaine use ( Lengvenyte et al., 2022 ), and in view of the presence of patients with a SUD within the sample of TRD patients collected for the observational, retrospective, multicentre REAL-ESK study ( Martinotti et al., 2022 Martinotti et al., 2023 ) and treated with ESK-NS, we provide here a prelimi- During the maintenance phase, ESK-NS dosing should be individualized to the lowest frequency to maintain remission/response The need for continued treatment should be re-examined periodically nary overview of its effectiveness and safety in this category of patients. Intranasal esketamine (ESK-NS), the S-enantiomer of ketamine, has recently emerged as a treatment for TRD, showing both rapid antidepressant action and good efficacy and high safety not only in experimental but also in naturalistic settings ( McIntyre et al., 2021 Martinotti et al., 2022 Martinotti et al., 2023 Lengvenyte et al., 2022 ) It is also indicated for the acute short-term treatment of psychiatric emergency due to (MDD-PE) and for depressive symptoms in adults with MDD with acute suicidal thoughts or behavior (MDSI) ( Lengvenyte et al., 2022 ). Me and Mr J by Rachel McIntyre - review ‘Full of moral messages, but truly a weirdly beautiful love story of a teenager struggling to find herself’ smileyblondeee Fri 04.00 EDT Last.
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